History of the discovery and clinical translation of prostate-specific antigen
نویسنده
چکیده
In recent years, there has been considerable controversy concerning the discovery and translation into clinical practice of the prostate-specific antigen (PSA) [1e4]. In this brief review, I offer the relevant historical facts as I believe them to be true. Before the development of the PSA blood test, prostatic acid phosphatase was the most important blood test for prostate cancer, but it was of no value for the early detection of prostate cancer, because serum acid phosphatase levels became elevated mainly in men who already had bone metastases [5].
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